The results were published online on April 16, , in Nature Genetics. Past studies had identified more than 50 genetic regions associated with lupus. Most are thought to be involved in gene regulation. The team found that a viral protein called EBNA2 was associated with nearly half of the genetic regions associated with the risk for lupus. EBNA2 is known to work through human transcription factors, which bind to DNA and affect the expression of genes nearby. The team also used RELI to compare the genetic regions tied to risk of other autoimmune diseases.
They found that EBNA2 bound to regions associated with the risk for multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, type 1 diabetes, juvenile idiopathic arthritis, and celiac disease. Many transcription factors were associated with these regions as well. Anthony S. References: Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity. El virus de Epstein-Barr y la mononucleosis infecciosa: Lo que debe saber. Links with this icon indicate that you are leaving the CDC website.
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EBV spreads most commonly through bodily fluids, especially saliva. However, EBV can also spread through blood and semen during sexual contact, blood transfusions, and organ transplantations. EBV can be spread by using objects, such as a toothbrush or drinking glass, that an infected person recently used. The virus probably survives on an object at least as long as the object remains moist.
The first time you get infected with EBV primary EBV infection you can spread the virus for weeks and even before you have symptoms. Once the virus is in your body, it stays there in a latent inactive state. If the virus reactivates, you can potentially spread EBV to others no matter how much time has passed since the initial infection.
Diagnosing EBV infection can be challenging because the symptoms are similar to other illnesses. EBV infection can be confirmed with a blood test that detects antibodies. About nine out of ten of adults have antibodies that show that they have a current or past EBV infection.
For more information, see Laboratory Testing. There is no vaccine to protect against EBV infection.
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